Aggrastat

tirofiban

By Medicines Co

What is this medication for?

Tirofiban belongs to the family of medications known as anti-platelets, and specifically to the family of anti-platelets known as GP IIb/IIIa inhibitors. Platelets are a component of the blood that is very important to blood clotting. Heart attacks are caused by blood clots that block the required flow of blood to the heart. Tirofiban is used in combination with heparin (a medication also used to prevent blood clots) and aspirin to prevent an early heart attack for people who have unstable angina (chest pain that gets worse with time and puts one at risk for heart attack) or a type of heart attack known as a non-Q-wave myocardial infarction.

Your doctor may have suggested this medication for conditions other than those listed here. As well, some forms of this medication may not be used for all of the conditions discussed here. If you are not sure why you are using this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Aggrastat® is available as:

  • injectable
    • 0.05 mg per mL
Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

How should I use this medication?

The recommended dose and dosing schedule of tirofiban varies according to body weight. Tirofiban is usually injected into a vein through a specially prepared site on your skin. Very careful handling of this medication is required. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation. The medication is usually given for a period of at least 48 hours.

Who should NOT take this medication?

Do not use this medication if you:

  • are allergic to tirofiban or any ingredients of the medication
  • are using any other injectable medications of the same type as tirofiban
  • have a history, symptoms, or signs of aortic dissection
  • have active internal bleeding or a history of any factors, such as medical conditions or medications, that increase bleeding risk
  • have any blood clotting disorder or have thrombocytopenia (low level of platelets)
  • have developed thrombocytopenia (low level of platelets) following previous use of tirofiban or a similar medication
  • have had a stroke within the 30 days before hospitalization or have ever had a hemorrhagic (bleeding) stroke
  • have had any major surgical procedure or severe physical trauma within the previous month
  • have had intracranial (in the brain) bleeding or tumor, artery and vein malformation, or an aneurysm
  • have severe high blood pressure that is not under control
  • have pericarditis
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The contents of this health site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.

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