By Shire

What side effects are possible with this medication?

A side effect is an unwanted response to a medication when it is taken in normal doses and cannot be anticipated. It can be mild or severe, temporary or permanent, but does not occur in everyone. The following side effects have been reported by at least 5% of people taking this medication. If you develop any of these side effects (or any other side effects not listed here) or they change in intensity, speak to your doctor or pharmacist for advice on managing them and on the risks and benefits of the medication.

  • abdominal pain
  • back pain
  • chest pain
  • cough
  • diarrhea
  • dizziness
  • feeling of pounding heartbeat
  • feeling unwell
  • fever
  • gas
  • headache
  • heartburn
  • itchiness
  • loss of appetite
  • nausea
  • pain
  • rapid heart rate
  • rash
  • shortness of breath
  • sore throat
  • swelling
  • tingling, prickling, or numbness of the skin
  • trouble breathing
  • vomiting
  • weakness/tiredness
Click here to learn about serious side effects that can potentially occur with any medication. These examples are provided for information purposes only and are not meant to be exhaustive. Always consult your doctor for sound medical advice specific to your particular medication and treatment.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone at 1-800-332-1088.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Heart disease: Anagrelide can cause an increased heart rate, a feeling of a racing or pounding heartbeat, swelling in the legs or ankles, and trouble breathing. If you have heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Laboratory monitoring: Your doctor may recommend blood tests before starting this medication and during treatment with this medication.

Kidney problems: Anagrelide may affect the function of the kidneys for those who already have kidney problems. You and your doctor will need to decide whether you should take this medication based on the importance of the medication to your health.

Liver disease: If you have a history of liver problems, your doctor should monitor your liver function closely while you are taking this medication. People with severe liver dysfunction should not take this medication. If you have mild-to-moderate liver dysfunction, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.  

Lung disease: Rarely, this medication has been associated with lung diseases, including allergic alveolitis, eosinophlic pneumonia, and interstitial pneumonitis. This may occur one week to several years after starting treatment with anagrelide. Talk to your doctor if you have any concerns.

Pregnancy: Anagrelide should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if this medication passes into breast milk. If you are a breast-feeding mother and are taking anagrelide, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

What other drugs could interact with this medication?

There may be an interaction between anagrelide and any of the following:

  • acetylsalicylic acid (aspirin)
  • cilastazol
  • enoximone
  • fluvoxamine
  • milrinone
  • olprinone
  • sucralfate
  • theophylline

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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The contents of this health site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.

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