alprostadil urethral suppository

By Vivus

What side effects are possible with this medication?

A side effect is an unwanted response to a medication when it is taken in normal doses. A side effect may be mild or severe, temporary or permanent, but does not occur in everyone. Not everyone will experience side effects, and which side effects a person experiences cannot be anticipated.

The following side effects have been reported by at least 1% of people taking this medication. If you develop any of these side effects (or any other side effects not listed here) or they change in intensity, speak to your doctor or pharmacist for advice on managing them and on the risks and benefits of the medication.

  • back pain
  • dizziness
  • flu symptoms
  • headache
  • hypotension
  • pain in the penis, urethra, or testes
  • pelvic pain
  • runny nose
  • urethral bleeding/spotting and minor abrasions of the urethra
  • urethral burning
Click here to learn about serious side effects that can potentially occur with any medication. These examples are provided for information purposes only and are not meant to be exhaustive. Always consult your doctor for sound medical advice specific to your particular medication and treatment.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone at 1-800-332-1088.

Are there any other precautions or warnings for this medication?

Be sure to inform your doctor of all your medical conditions before you begin taking a medication. Some conditions can affect how you should take this medication.

Bleeding: If the medication is not inserted properly, you may have small cuts or scrapes in the urethra. People with bleeding disorders or those taking blood thinners may be at a higher risk of bleeding and should be closely monitored by their doctor while they are taking this medication. The small cuts or scrapes in the urethra also increase the risk of passing sexually transmitted infections between sexual partners.

Occupational hazards: Fainting, low blood pressure, and dizziness may occur with the use of this medication. Avoid activities such as driving or operating machinery during this time.

Priapism: A prolonged and rigid erection (greater than 6 hours) should be reported to your doctor immediately.

Women and children: This medication is not recommended for women or children. Men who are having intercourse with a pregnant woman should use a condom to protect the developing child from being exposed to this medication.

What other drugs could interact with this medication?

An interaction between medications does not always mean that you must stop taking one of them. The following medications may affect the way alprostadil works, be affected by alprostadil, or increase the risk of side effects:

  • anticoagulants (e.g., warfarin, heparin, dalteparin)
  • anti-hypertensive medications (e.g. hydralazine)

If you are taking any of these or other medications (including non-prescription, herbal, and supplement products), speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want to change your therapy or may suggest ways of managing any interactions. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your doctor know if you use them. Medications other than those listed above may also interact with this medication.

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The contents of this health site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.

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