Agenerase

amprenavir

By GlaxoSmithKline

What side effects are possible with this medication?

A side effect is an unwanted response to a medication when it is taken in normal doses. A side effect may be mild or severe, temporary or permanent, but does not occur in everyone. Not everyone will experience side effects, and which side effects a person experiences cannot be anticipated.

The following side effects have been reported by at least 1% of people taking this medication. If you develop any of these side effects (or any other side effects not listed here) or they change in intensity, speak to your doctor or pharmacist for advice on managing them and on the risks and benefits of the medication.

  • abdominal pain
  • change in taste sensation
  • depression or mood changes
  • diarrhea
  • fatigue
  • headache
  • increased blood glucose (hyperglycemia)
  • increased cholesterol levels
  • increased hunger
  • increased thirst
  • increased urination
  • muscle soreness or pain
  • nausea
  • numbness or "needles and pins" feeling on the face or limbs
  • skin rash
  • vomiting
  • weight gain

If you are taking the oral solution:

  • confusion
  • rapid heart rate
Click here to learn about serious side effects that can potentially occur with any medication. These examples are provided for information purposes only and are not meant to be exhaustive. Always consult your doctor for sound medical advice specific to your particular medication and treatment.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone at 1-800-332-1088.

Are there any other precautions or warnings for this medication?

Be sure to inform your doctor of all your medical conditions before you begin taking a medication. Some conditions can affect how you should take this medication.

Birth control: Hormonal birth control pills will reduce the effectiveness of amprenavir. Your doctor may advise that you stop using hormonal birth control pills while taking amprenavir. An alternate non-hormonal birth control method (e.g. condoms) should be used to prevent pregnancy.

Bleeding risk: People with hemophilia may be more likely to bleed while taking this medication.

Body fat: People taking this medication have noticed redistribution or accumulation of body fat. This can lead to a "buffalo hump" (fat deposits on the back), breast enlargement, rounding of the abdomen or face. The cause and long-term effects of this problem are unknown.

Diabetes: This medication may cause worsening of blood glucose (sugar) control for people with diabetes. It may also increase the risk of developing diabetes. People with diabetes should monitor their blood sugar closely while taking this medication.

Drug interactions: There are life-threatening interactions that can occur between amprenavir and many other medications. For your safety, if you are thinking about or using any other medication, prescription or non-prescription, you should check with your doctor or pharmacist first. See the "What other drugs could interact with this medication?" section for more details.

High cholesterol: This medication can cause high cholesterol levels in some people. The doctor may require that you get your cholesterol levels tested before starting this medication and then every few months to monitor your cholesterol levels.

Skin allergic reactions: This medication has been associated with a life-threatening skin allergic reaction in 1% of people called "Stevens-Johnson syndrome", if you have experienced any skin allergic reactions or have known drug allergies (e.g., sulfa allergy), tell your doctor before taking this medication.

Liver disease: People who have liver disease should be closely monitored by their doctors while they are taking amprenavir.

Oral solution: Amprenavir oral solution contains a large amount of propylene glycol and should not be used by people with liver disease or by children younger than four years of age.

Sulfa drug allergy: Amprenavir is a sulfonamide (sulfa medication). If you are allergic to sulfa medications, you may also be allergic to amprenavir. Talk to your doctor or pharmacist if you are allergic to sulfa medications.

Vitamin E: Amprenavir capsules and oral solution contain high doses of vitamin E.

  • Each 50 mg amprenavir capsule contains 36.3 IU (international units) of vitamin E.
  • Each millilitre of oral solution contains 46 IU of vitamin E.

Do not take vitamin E supplements unless directed by your doctor. The total amount of vitamin E in your body from taking amprenavir with a vitamin E supplement will result in more than the daily recommended maximum.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if amprenavir passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of this medication have not been established for children less than 4 years of age.

What other drugs could interact with this medication?

An interaction between medications does not always mean that you must stop taking one of them. The following medications may affect the way amprenavir works, be affected by amprenavir, or increase the risk of side effects:

  • alcohol
  • antacids
  • antiarrhythmic medications (e.g., amiodarone, lidocaine, quinidine, bepridil)
  • anticonvulsants (e.g., carbamazepine, phenytoin, phenobarbital)
  • anti-HIV medications (e.g., delavirdine, didanosine, efavirenz, indinavir, lopinavir, nelfinavir, nevirapine, ritonavir oral solution [with amprenavir oral solution], saquinavir, zidovudine)
  • azole antifungals (e.g., itraconazole, ketoconazole)
  • benzodiazepines (e.g., diazepam, midazolam, triazolam)
  • calcium channel blockers (e.g., diltiazem, nifedipine)
  • cimetidine
  • cisapride
  • dexamethasone
  • disulfiram
  • ergot derivatives (e.g., dihydroergotamine, ergotamine, ergonovine, methylergonovine)
  • flecainide or propafenone (if using amprenavir with ritonavir)
  • fluticasone (inhaler or nasal spray)
  • hormonal birth control pills
  • hormones (e.g., estrogen, progesterone)
  • immunosuppressants (e.g. cyclosporine, tacrolimus, rapamycin)
  • macrolide antibiotics (e.g., clarithromycin, erythromycin)
  • methadone
  • metronidazole
  • pimozide
  • rifabutin
  • rifampin
  • sildenafil
  • St. John's wort
  • statins or anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
  • trazodone
  • tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine)
  • vitamin E
  • warfarin

If you are taking any of these or other medications (including non-prescription, herbal, and supplement products), speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to change your therapy or suggest ways of managing any interactions. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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The contents of this health site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.

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